Avantea & OPU-ICSI: From Alternative Solution to Cornerstone of Modern Breeding

Female Fertility and Reproductive Success

Avantea, a European leader in assisted equine reproduction, highlights how OPU-ICSI—originally developed as a solution for subfertile mares or stallions with limited semen availability—has now become a cornerstone of modern reproductive planning.

OPU-ICSI: Measurable Efficiency, Tangible Results

One of the key reasons behind the widespread adoption of this technique is its high efficiency. Data collected by Avantea show that OPU-ICSI offers significantly higher success rates than traditional flushing, providing greater predictability in planning and lowering the cost per embryo produced. This gives breeders a strategic advantage when it comes to maximizing the number of embryos per session and managing genetic resources effectively.

Versatility: Suitable Even for the Most Challenging Cases

OPU-ICSI has proven to be a versatile and universal technique, successfully applicable to young mares, active sport mares, older mares, or those with reduced fertility. In many of these cases, flushing is less effective—or even unfeasible—making OPU-ICSI the only truly viable option. As a result, the technique has become central to breeding strategies focused on results and genetic continuity.

An Animal-Welfare Friendly Procedure

One of the most valued aspects by breeders is the minimal impact the procedure has on the donor mare. OPU, or transvaginal ultrasound-guided oocyte retrieval, is performed under controlled sedation without the need for intensive hormonal treatments or uterine manipulation. The mare can return to her usual activities quickly, which is a clear benefit for her overall well-being. In contrast, flushing often involves more invasive and repeated procedures.

Time and Resource Optimization

A major strength of OPU-ICSI lies in the simplification of reproductive logistics. Unlike flushing, which requires frequent monitoring and synchronization between donor and recipient mares, OPU-ICSI only requires intervention on the day of oocyte collection. Embryos can be frozen for later use—at any time of year—allowing for greater flexibility in breeding programs and more rational time management.

Cost Efficiency and Maximum Yield

From a financial perspective, the technique is also advantageous. The high yield per session, combined with more efficient use of semen, helps keep costs under control and eliminates many of the additional expenses associated with flushing (such as prolonged monitoring or synchronization costs). In a rationally managed program, this translates into a better return on investment.

A Fully Integrated Ecosystem for Equine Reproduction

OPU-ICSI is more than just a technique—it’s the core of a comprehensive system. Avantea offers a wide range of integrated services that support every phase of the reproductive process:

• Semen and embryo banking, allowing genetic material to be stored and used at the optimal time;
• Embryo sexing and genetic screening, enabling more informed decisions prior to transfer;
• Recipient mare leasing and clinical management, as part of a full-service approach;
• A European network of partner clinics, allowing OPU procedures to be performed locally while centralizing ICSI at Avantea’s state-of-the-art labs.

This synergy of expertise and infrastructure provides breeders with advanced tools that are simply not replicable through traditional methods.

The efficiency of OPU-ICSI, combined with respect for animal welfare and logistical flexibility, makes it an indispensable resource for quality breeding. Avantea continues to invest in research and innovation to make the technique even more accessible and effective, supporting breeders with a scientific, comprehensive, and results-driven approach.

For more information on how to integrate OPU-ICSI into your breeding program, you can contact the center directly or subscribe to the newsletter available on the official website.

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